Teplizumab delays onset of type 1 diabetes mellitus
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چکیده
منابع مشابه
Teplizumab Preserves C-Peptide in Recent-Onset Type 1 Diabetes
Protégé was a phase 3, randomized, double-blind, parallel, placebo-controlled 2-year study of three intravenous teplizumab dosing regimens, administered daily for 14 days at baseline and again after 26 weeks, in new-onset type 1 diabetes. We sought to determine efficacy and safety of teplizumab immunotherapy at 2 years and to identify characteristics associated with therapeutic response. Of 516...
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mptomatic diabetes as a manifestation of another underng condition is uncommon, and usually due to the use drugs with hyperglycemic potential or to neoplastic prosses in the pancreatic area. Among drugs, special mention uld be made of high-dose steroids and, more recently d in young patients, atypical neuroleptics.1 The onset of rdinal symptoms of diabetes mellitus (DM) in a patient der 40 year...
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Serum levels of apolipoprotein CIII (apoCIII) are increased in type 1 diabetic patients, and when β cells are exposed to these diabetic sera, apoptosis occurs, an effect abolished by an antibody against apoCIII. We have investigated the BB rat, an animal model that develops a human-like type 1 diabetes, and found that apoCIII was also increased in sera from prediabetic rats. This increase in ap...
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ژورنال
عنوان ژورنال: Nature Reviews Endocrinology
سال: 2019
ISSN: 1759-5029,1759-5037
DOI: 10.1038/s41574-019-0233-3